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Rejuvenation Research

Noninvasive Neonatal Thymus Graft into the Axillary Cavity Extends the Lifespan of Old Mice

To cite this article:
Andrea Basso, Marco Malavolta, Francesco Piacenza, Lory Santarelli, Fiorella Marcellini, Roberta Papa, and Eugenio Mocchegiani. Rejuvenation Research. May 2010, 13(2-3): 288-291. https://doi.org/10.1089/rej.2009.0936

Published in Volume: 13 Issue 2-3: May 12, 2010
Online Ahead of Print: December 2, 2009

Author information

Andrea Basso,¹ Marco Malavolta,¹ Francesco Piacenza,² Lory Santarelli,² Fiorella Marcellini,¹ Roberta Papa,¹ and Eugenio Mocchegiani¹

¹INRCA, Scientific and Technological Research, Ancona, Italy.

²Department of Molecular Pathology and Innovative Therapies, Occupational Medicine, Polytechnic University of Marche, Torrette, Ancona, Italy.

Address correspondence to:

Dr. Eugenio Mocchegiani

INRCA, Scientific and Technological Research

via Birarelli 8

60100, Ancona

Italy
E-mail: e.mocchegiani@inrca.it

ABSTRACT

Neonatal thymus grafts exert a rejuvenating action on various immunological and nonimmunological functions found altered in old mice. Commonly, half of a thymus is grafted under the kidney capsule. The invasiveness of the surgical procedure and the use of limited thymus tissue may explain why precedent survival kinetics remain unaffected. In this trial, we grafted two neonatal thymi into the axillary cavity of old mice, thus reducing the invasiveness of the intervention and increasing the amount of grafted neonatal tissue. Using a Piantanelli parametric model of survivorship, we found a significant change in mortality rate between the two groups (thymus graft and controls).

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