Skip Navigation

Journal of Computational Biology

Not a subscriber? Get started...

Prediction of Membrane Proteins in Mycobacterium tuberculosis Using a Support Vector Machine Algorithm

To cite this article:
Joanne I. Yeh and Lisong Mao and. Journal of Computational Biology. January/February 2006, 13(1): 126-129. doi:10.1089/cmb.2006.13.126.

Published in Volume: 13 Issue 1: February 10, 2006

Full Text PDF (89.6 KB)
Full Text PDF with Links (107.5 KB)

Author information

Joanne I. Yeh

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 20906.

Department of Chemistry, Brown University, Providence, RI 20906.

Current address: University of Pittsburgh Medical School, Department of Structural Biology, 3501 5th Avenue, Pittsburgh, PA 15260.

Lisong Mao

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 20906.

ABSTRACT

We report our finding of linear clustering of signal sequences at the N-terminus of M.tb membrane proteins, directing membrane localization. Although it is widely accepted that membrane proteins have signal peptides at the N-terminus, statistical ensemble analysis of Support Vector Machine prediction results indicate that M.tb membrane proteins have embedded N-terminal sequence patterns beyond the signal peptides previously identified in E. coli. The additional patterns at the N-terminus of M.tb membrane proteins may have correlations to their unique enzymatic functions and unusual characteristics such as membrane interaction in pathogenes

Free first page

This paper was cited by:

CE-PLoc: An ensemble classifier for predicting protein subcellular locations by fusing different modes of pseudo amino acid composition

Asifullah Khan, Abdul Majid, Maqsood Hayat

Computational Biology and Chemistry. Aug 2011, Vol. 35, No. 4: 218-229

Prediction of subcellular location of mycobacterial protein using feature selection techniques

Hao Lin, Hui Ding, Feng-Biao Guo, Jian Huang

Molecular Diversity. Nov 2010, Vol. 14, No. 4: 667-671

Users who read this article also read

full access

A Polynomial-Time Algorithm for De Novo Protein Backbone Structure Determination from Nuclear Magnetic Resonance Data

Lincong Wang, Ramgopal R. Mettu, Bruce Randall Donald

Journal of Computational Biology. September 2006: 1267-1288.

Abstract | Full Text PDF | Reprints | Permissions

full access

Wavelet Analysis of DNA Walks

Adrian D. Haimovich, Bruce Byrne, Ramakrishna Ramaswamy, William J. Welsh

Journal of Computational Biology. September 2006: 1289-1298.

Abstract | Full Text PDF | Reprints | Permissions

full access

Pseudoknots in RNA Secondary Structures: Representation, Enumeration, and Prevalence

Einar Andreas Rødland

Journal of Computational Biology. July/August 2006: 1197-1213.

Abstract | Full Text PDF | Reprints | Permissions

full access

Detecting Conserved Interaction Patterns in Biological Networks

Mehmet Koyutürk, Yohan Kim, Shankar Subramaniam, Wojciech Szpankowski, Ananth Grama

Journal of Computational Biology. September 2006: 1299-1322.

Abstract | Full Text PDF | Reprints | Permissions

full access

Efficient Algorithms for Detecting Signaling Pathways in Protein Interaction Networks

Jacob Scott, Trey Ideker, Richard M. Karp, Roded Sharan

Journal of Computational Biology. March 2006: 133-144.

Abstract | Full Text PDF | Reprints | Permissions

full access

Designing an A* Algorithm for Calculating Edit Distance between Rooted-Unordered Trees

Yair Horesh, Ramit Mehr, Ron Unger

Journal of Computational Biology. July/August 2006: 1165-1176.

Abstract | Full Text PDF | Reprints | Permissions

Publication Tools

Share & Recommend

Related articles in Liebert Online